{
 "drug": "Insulin Lispro Protamine and Insulin Lispro Injection",
 "asOf": "2026-10-09",
 "status": "discontinuing",
 "since": "09/01/2026",
 "dayN": 38,
 "cat": "Endocrinology/Metabolism",
 "companies": [
  "Eli Lilly and Co."
 ],
 "reasons": [],
 "records": [
  {
   "discontinued_date": "09/01/2026",
   "update_type": "New",
   "initial_posting_date": "09/01/2026",
   "package_ndc": "0002-8233-05",
   "generic_name": "Insulin Lispro Protamine and Insulin Lispro Injection",
   "contact_info": "800-545-5979",
   "related_info": "A business decision was made to discontinue manufacture of the drug. Distribution projected to end June 2027. If patients or prescribers have any questions, the Lilly Answers Center (1-800-545-5979) is available Monday through Friday from 9am to 8pm for assistance.",
   "openfda": {
    "application_number": [
     "BLA021017"
    ],
    "brand_name": [
     "INSULIN LISPRO PROTAMINE AND INSULIN LISPRO INJECTABLE SUSPENSION MIX75/25 KWIKPEN"
    ],
    "generic_name": [
     "INSULIN LISPRO"
    ],
    "manufacturer_name": [
     "Eli Lilly and Company"
    ],
    "product_ndc": [
     "0002-8233"
    ],
    "product_type": [
     "HUMAN PRESCRIPTION DRUG"
    ],
    "route": [
     "SUBCUTANEOUS"
    ],
    "substance_name": [
     "INSULIN LISPRO"
    ],
    "rxcui": [
     "847252"
    ],
    "spl_id": [
     "03dce3f6-da85-4635-9c62-478226005b60"
    ],
    "spl_set_id": [
     "e49f701d-c19f-4cb2-b63f-01a917b33abc"
    ],
    "package_ndc": [
     "0002-8233-01",
     "0002-8233-05"
    ],
    "nui": [
     "N0000004931",
     "N0000175453"
    ],
    "pharm_class_cs": [
     "Insulin [Chemical/Ingredient]"
    ],
    "pharm_class_epc": [
     "Insulin Analog [EPC]"
    ],
    "unii": [
     "GFX7QIS1II"
    ]
   },
   "update_date": "09/01/2026",
   "therapeutic_category": [
    "Endocrinology/Metabolism"
   ],
   "dosage_form": "Injection",
   "presentation": "Humalog Mix 75/25, Injection, 100 [iU]/1 mL (NDC 0002-8233-05)",
   "company_name": "Eli Lilly and Co.",
   "status": "To Be Discontinued"
  }
 ],
 "firstSeen": "2026-09-03",
 "history": [
  {
   "date": "2026-09-03",
   "kind": "new",
   "to": "discontinuing",
   "text": "Insulin Lispro Protamine and Insulin Lispro Injection appeared on the FDA shortage list (being discontinued)"
  }
 ]
}