{
 "drug": "Lorlatinib Tablet",
 "asOf": "2026-08-25",
 "status": "discontinuing",
 "since": "06/15/2026",
 "dayN": 71,
 "cat": "Oncology",
 "companies": [
  "Pfizer Inc."
 ],
 "reasons": [],
 "records": [
  {
   "discontinued_date": "06/15/2026",
   "update_type": "New",
   "initial_posting_date": "06/15/2026",
   "package_ndc": "0069-0227-03",
   "generic_name": "Lorlatinib Tablet",
   "contact_info": "800-533-4535",
   "related_info": "Supply expected to exhaust 6/30/2026; NDC 0069-0227-01 25 mg; 30 tablets bottle with a child-resistant closure will continue to be manufactured; Discontinuation of the manufacture of this presentation",
   "openfda": {
    "application_number": [
     "NDA210868"
    ],
    "brand_name": [
     "LORBRENA"
    ],
    "generic_name": [
     "LORLATINIB"
    ],
    "manufacturer_name": [
     "Pfizer Laboratories Div Pfizer Inc"
    ],
    "product_ndc": [
     "0069-0227",
     "0069-0231"
    ],
    "product_type": [
     "HUMAN PRESCRIPTION DRUG"
    ],
    "route": [
     "ORAL"
    ],
    "substance_name": [
     "LORLATINIB"
    ],
    "rxcui": [
     "2103169",
     "2103175",
     "2103177",
     "2103179"
    ],
    "spl_id": [
     "46cb56ce-da15-49af-b72b-f9e377cae4a6"
    ],
    "spl_set_id": [
     "2b34d62d-e02a-4af3-bc0d-1571dd4ee76d"
    ],
    "package_ndc": [
     "0069-0227-01",
     "0069-0227-03",
     "0069-0231-01"
    ],
    "nui": [
     "N0000175605",
     "N0000175082",
     "N0000190118",
     "N0000191264",
     "N0000187064",
     "N0000191265",
     "N0000190111",
     "N0000191423",
     "N0000190113"
    ],
    "pharm_class_epc": [
     "Kinase Inhibitor [EPC]"
    ],
    "pharm_class_moa": [
     "Kinase Inhibitors [MoA]",
     "Cytochrome P450 3A Inducers [MoA]",
     "P-Glycoprotein Inducers [MoA]",
     "Cytochrome P450 2B6 Inducers [MoA]",
     "Organic Cation Transporter 1 Inhibitors [MoA]",
     "Organic Anion Transporter 3 Inhibitors [MoA]",
     "Multidrug and Toxin Extrusion Transporter 1 Inhibitors [MoA]",
     "Breast Cancer Resistance Protein Inhibitors [MoA]"
    ],
    "unii": [
     "OSP71S83EU"
    ]
   },
   "update_date": "06/15/2026",
   "therapeutic_category": [
    "Oncology"
   ],
   "dosage_form": "Tablet",
   "presentation": "Lorbrena, Tablet, 25 mg; 120 tablets bottle with a child-resistant closure (NDC 0069-0227-03)",
   "company_name": "Pfizer Inc.",
   "status": "To Be Discontinued"
  }
 ]
}